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PKCδ knockdown was used to elucidate the role of PKCδ activation as a mechanism for the synergy. The synergistic interactions were determined by Calcusyn analysis. Methods: The antitumor effects of sorafenib, OSU-2S and their combination were assessed by MTT assay, caspase activation, Western blotting, migration/invasion assays in four different HCC cell lines.

OSU-2S, a PKCδ activator, was selected as a potential candidate anticancer agent to be combined with sorafenib to promote the anti-cancer activity through synergistic interaction. However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and strongly recommend its combination with other agents aiming at ameliorating its drawbacks. 5Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwanīackground: Sorafenib (Nexavar ®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC).4School of Pharmacy, Chapman University, Irvine, CA, USA.

3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.1Sharjah Institute for Medical Research and College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.Tolba 3,4, Jui-Hsiang Hung 5 and Taleb H. NOTE: On side note, if you do not want to install any plugins like this, I would recommend using the following 2 best online formatters.Hany A.

Select all text in Notepad++ (CTRL+A) and format using Plugins -> JSTool -> JSFormat. Paste a sample unformatted but valid JSON data in Notepad++. If it complains about incompatibility, go back to STEP 1 and download the correct bit version as per your OS. If you have downloaded an incompatible dll, then it will complain, else it will open successfully. Unzip the downloaded JSToolNPP.1.21.0.uni.64 and copy the JSMinNPP.dll and place it under C:\Program Files\Notepad++\plugins.Ĭlose Notepad++ and reopen it. 64bit - JSToolNPP.1.21.0.uni.64.zip: Download from Here are the steps to install JSToolNPP plugin on your Notepad++.ĭownload 64bit version from Sourceforge or theģ2bit version if you are on a 32-bit OS.